Genome-wide screen in human plasma identifies multifaceted complement evasion of Pseudomonas aeruginosa.
Pseudomonas aeruginosa, an opportunistic Gram-negative pathogen, is a leading cause of bacteremia with a high mortality rate.We recently reported that P.aeruginosa forms a persister-like sub-population of evaders in human plasma.Here, using a gain-of-function transposon sequencing (Tn-seq) screen in plasma, we identified and validated previously un